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Updated: Aug 8, 2026
10:01
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Clinical course of postinfectious bronchiolitis obliterans
L Zhang1, K Irion, H Kozakewich
1Departamento Materno-Infantil, Fundacao Universidade do Rio Grande, Rio Grande, Brazil. zhang@rgd.conesul.com.br
Pediatric Pulmonology
|May 2, 2000
Summary
Postinfectious bronchiolitis obliterans in young children can lead to persistent respiratory issues. Older age at onset and atopy indicate a poorer prognosis for these patients.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Clinical Pediatrics
Background:
- Postinfectious bronchiolitis obliterans (PIBO) is a rare but serious condition.
- It typically follows an acute respiratory infection in early childhood.
- Long-term outcomes and predictive factors for PIBO require further definition.
Purpose of the Study:
- To describe the clinical course of PIBO in young children.
- To identify prognostic factors associated with PIBO outcomes.
- To evaluate the long-term respiratory health in affected children.
Main Methods:
- Prospective observational study of 31 patients with PIBO.
- Exclusion of other causes of chronic airflow obstruction.
- Clinical data collection via standardized forms, chest imaging, lung scans, spirometry (in older patients), and lung biopsies.
Main Results:
- Mean follow-up of 3.5 years revealed varied clinical courses.
- Outcomes included clinical remission (22.6%), persistent symptoms (67.7%), and mortality (9.7%).
- Older age at onset and elevated serum IgE (indicating atopy) were linked to poor prognosis.
Conclusions:
- PIBO has a variable clinical course with a significant proportion experiencing persistent respiratory symptoms.
- Early-onset disease and atopy are critical indicators for predicting a worse prognosis in PIBO.
- Further research is needed to explore targeted interventions for improving PIBO outcomes.
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