Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth hormone and cardiac function.

G Lombardi1, C Di Somma, P Marzullo

  • 1Departement of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy.

Annales D'Endocrinologie
|May 3, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From diabetes to tumor growth: unravelling the impact of glucose-lowering therapies.

Endocrine·2026
Same author

The management of adrenocortical carcinoma in the era of precision medicine.

Critical reviews in oncology/hematology·2025
Same author

Nutritional assessment and medical dietary therapy for management of obesity in patients with non-dialysis chronic kidney disease: a practical guide for endocrinologist, nutritionists and nephrologists. A consensus statement from the Italian society of endocrinology (SIE), working group of the club nutrition-hormones and metabolism; the Italian society of nutraceuticals (SINut), club ketodiets and nutraceuticals "KetoNut-SINut"; and the Italian society of nephrology (SIN).

Journal of endocrinological investigation·2024
Same author

Long-term pasireotide therapy in acromegaly: extensive real-life experience of a referral center.

Journal of endocrinological investigation·2024
Same author

Ketogenic nutritional therapy (KeNuT)-a multi-step dietary model with meal replacements for the management of obesity and its related metabolic disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)-diet therapies in endocrinology and metabolism.

Journal of endocrinological investigation·2024
Same author

Disease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy.

Journal of endocrinological investigation·2024
Same journal

Corrigendum to 'Pink adipose tissue: A paradigm of adipose tissue plasticity' [Ann. Endocrinol. 85 (2004) 248-51].

Annales d'endocrinologie·2026
Same journal

Intraoperative location of parathyroid glands during total thyroidectomy: a systematic review of the literature according to the PRISMA method.

Annales d'endocrinologie·2026
Same journal

Clinical and genetic diagnosis of PHP1A associated with hypogonadism in a young male: A case report.

Annales d'endocrinologie·2026
Same journal

Autoimmune features in acquired generalized lipodystrophy and anti-perilipin 1 antibodies: A case report.

Annales d'endocrinologie·2026
Same journal

The diagnostic challenge of occult glucocorticoid exposure causing Cushing's syndrome.

Annales d'endocrinologie·2026
Same journal

ACTH-dependent Cushing's syndrome in MEN1: When multiple tumors complicate the diagnosis.

Annales d'endocrinologie·2026
See all related articles

Growth hormone (GH) impacts cardiovascular health, causing issues in both deficiency and excess. GH therapy shows promise for treating heart failure by improving cardiac function.

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • Cardiovascular dysfunction is linked to growth hormone (GH) and insulin-like growth factor-I (IGF-I) imbalances.
  • GH and IGF-I play roles in heart development and function.
  • Specific cardiac pathologies are associated with GH excess (acromegaly) and deficiency (GHD).

Purpose of the Study:

  • To investigate the cardiovascular effects of GH and IGF-I.
  • To explore the potential of GH therapy in managing cardiovascular conditions.

Main Methods:

  • Review of experimental and clinical studies on GH/IGF-I and cardiovascular function.
  • Analysis of cardiac structure and function in acromegaly and GHD patients.
  • Evaluation of GH replacement therapy outcomes in GHD and potential use in heart failure.

Related Experiment Videos

Main Results:

  • Acromegaly is associated with specific cardiomyopathy (hypertrophy, fibrosis, inflammation).
  • GH deficiency (GHD) presents with left ventricular abnormalities and increased atherosclerosis.
  • Cardiovascular abnormalities may be reversible with GH/IGF-I level modulation or GH therapy.
  • GH administration showed potential to improve hemodynamics and clinical status in heart failure patients.

Conclusions:

  • GH and IGF-I significantly influence cardiovascular health.
  • GH therapy may offer new therapeutic avenues for chronic heart failure.
  • Further controlled studies are needed to confirm GH's efficacy in heart failure treatment.