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Updated: Aug 5, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
[Role of monoaminergic system in the mechanisms of developing a dependence on morphine]
M A Filonenko1, V Ia Pishel', I M Pishel'
1Institute of Pharmacology and Toxicology of Academy of Medical Science of Ukraine.
Abstract:
The influence of morphine chronic administration on the neuromediators contents in various structures of brain has been studied. It has been shown that the development of physical dependence on the morphine and abstinence syndrome is accompanied by reduction of activity of serototinergic system, which is manifested in decrease of serotonin and its precursor tryptophane levels. Adrenergic and dophaminergic systems do not react to the development and abstinence by changes of the contents of monoamines that testifies of interaction of opioid and neuromediator systems disturbance.
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