White cells 2: impact of understanding the molecular basis of haematological malignant disorders on clinical practice
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Updated: Mar 2, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
1Department of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada. k.stewart@utoronto.ca
Abstract:
The molecular basis of many leukaemias is now known, allowing precise diagnosis. Treatment of chronic myeloid leukaemia is now possible by targeting of the BCR-ABL tyrosine kinase. The underlying molecular abnormalities in acute leukaemias allow the outlook for individual patients to be assessed at diagnosis and therapy tailored accordingly. Analysis of V(H) genes in B-cell malignant disorders allows these to be placed in the hierarchy of B-cell development and may provide prognostically valuable information.
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