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Apoptosis in acute pancreatitis
Z J He1, I Podkletnova, H Alho
1Department of Surgery, Tampere University Hospital, Finland.
Background:
Apoptosis may be involved in the mechanism of acinar cell injury in acute experimental pancreatitis.
Aim:
This study was to investigate whether apoptosis also is involved in human acute pancreatitis.
Method:
A needle biopsy pancreatic specimen was obtained from a patient with acute oedematous pancreatitis. The specimen was stained with In Situ Cell Death Detection Kit. Similar specimen from a patient undergoing pancreatoduodenectomy for bile duct cancer served as a control.
Results:
Extended acinar cell apoptosis was found in the pancreatitis specimen. No single apoptotic cell was found in the control pancreas.
Conclusion:
Apoptosis probably is involved not only in acute experimental pancreatitis but also in human acute oedematous pancreatitis. The induction and role of apoptosis in pancreatis is discussed based on literature.
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
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