Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of serum carotenoids in Crohn's disease.

G Rumi1, I Szabó, A Vincze

  • 1First Department of Medicine, University Medical School of Pécs, Hungary.

Journal of Physiology, Paris
|May 3, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PlomBOX: a low cost bioassay for the sensitive detection of lead in drinking water.

Communications engineering·2025
Same author

Acquired cow's milk sensitization after liver transplant in an adult: "clinical implications" and future strategies.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2019
Same author

Improvement of quality of life in allergic rhinoconjunctivitis patients using nasal filters, a preliminary study.

European annals of allergy and clinical immunology·2013
Same author

Lipid transfer proteins: the most frequent sensitizer in Italian subjects with food-dependent exercise-induced anaphylaxis.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2012
Same author

Effects of pituitary adenylate cyclase activating polypeptide on human sperm motility.

Journal of molecular neuroscience : MN·2012
Same author

PACAP is an endogenous protective factor-insights from PACAP-deficient mice.

Journal of molecular neuroscience : MN·2012
Same journal

Role of synchronized physiological and interpersonal rhythms in typical and atypical development.

Journal of physiology, Paris·2017
Same journal

Suicide attempts in children and adolescents: The place of clock genes and early rhythm dysfunction.

Journal of physiology, Paris·2017
Same journal

Editorial.

Journal of physiology, Paris·2017
Same journal

Dyssynchrony and perinatal psychopathology impact of child disease on parents-child interactions, the paradigm of Prader Willi syndrom.

Journal of physiology, Paris·2017
Same journal

Key considerations in designing a speech brain-computer interface.

Journal of physiology, Paris·2017
Same journal

Links between early child maltreatment, mental disorders, and cortisol secretion anomalies.

Journal of physiology, Paris·2017
See all related articles

Crohn's disease patients show significantly lower levels of vitamin A and other carotenoids compared to healthy individuals. While levels improved with treatment, the changes were not statistically significant, suggesting potential deficiencies.

Area of Science:

  • Gastroenterology and Nutritional Science

Background:

  • Crohn's disease (CD) frequently leads to nutritional disturbances, yet vitamin status in patients remains under-documented.
  • Understanding carotenoid levels, including vitamin A, is crucial for managing CD complications.

Purpose of the Study:

  • To quantify serum concentrations of vitamin A and six carotenoids in CD patients versus healthy controls.
  • To monitor changes in serum carotenoid levels in CD patients during a one-year treatment period.

Main Methods:

  • Serum carotenoid levels (vitamin A, lutein, zeaxanthin, alpha-carotene, beta-carotene, alpha-cryptoxanthin, beta-cryptoxanthin) were measured using high-pressure liquid chromatography (HPLC).
  • Study included 28 CD patients and 23 healthy controls; 12 CD patients were followed for one year.
  • Patients received no specific nutritional treatment during the follow-up period.

Related Experiment Videos

Main Results:

  • CD patients exhibited significantly lower serum concentrations of vitamin A, zeaxanthin, alpha-carotene, beta-carotene, and lutein compared to controls.
  • Follow-up showed a trend towards improved carotenoid status in CD patients, but these increases were not statistically significant.
  • Vitamin A and provitamin deficiencies are indicated in Crohn's disease patients before treatment.

Conclusions:

  • Pre-treatment Crohn's disease is associated with deficiencies in vitamin A and its provitamins.
  • Further research is needed to determine the relative contributions of poor intake, increased requirements, or malabsorption to these deficiencies.
  • While carotenoid levels showed improvement during treatment, the lack of statistical significance warrants further investigation.