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Management of cerebral vasculopathy in children with sickle cell anaemia

D R Powars1

  • 1Department of Paediatrics, Hematology/Oncology Division, University of Southern California School of Medicine, Los Angeles, CA 90033, USA. powars@hsc.usc.edu

British Journal of Haematology
|May 3, 2000
PubMed
Abstract

No abstract available in PubMed .

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Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

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