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Inverse relation between plasma G-CSF levels and neutrophil counts in a patient with autoimmune neutropenia treated
1Department of Internal Medicine and Department of Clinical Chemistry, Diaconessenhuis, Eindhoven, The Netherlands.
Abstract:
The pharmacokinetic characteristics of granulocyte colony-stimulating factor (G-CSF) appears to be related to the neutrophil count. We report the case of an 81-year-old male with acquired antibody induced neutropenia treated with G-CSF. This produced a rapid increase in the neutrophil count which appeared to be associated with diminished trough plasma G-CSF levels. Our data appears to indicate that mature neutrophils may play a part in the clearance of G-CSF from plasma.
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