Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphological and immunophenotypic variations in malignant melanoma.

S S Banerjee1, M Harris

  • 1Department of Histopathology, Christie Hospital, Manchester, UK.

Histopathology
|May 3, 2000
PubMed
Summary

Malignant melanomas exhibit diverse cytomorphological and architectural features, often mimicking other tumors. Understanding these variations is crucial for accurate diagnosis and effective treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.

The Journal of biological chemistry·1996
Same author

TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man.

Journal of immunology (Baltimore, Md. : 1950)·1995
Same author

Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation.

Journal of neurochemistry·1995
Same author

Episodically homeless women with serious mental illness: prevalence of physical and sexual assault.

The American journal of orthopsychiatry·1995
Same author

Autologous blood stem cell transplantation for haematological malignancy: treatment-related mortality of 2%.

Australian and New Zealand journal of medicine·1995
Same author

Treatment and survival of lymphoid malignancy in the north-west of England: a population-based study.

British journal of cancer·1995

Area of Science:

  • Pathology
  • Oncology
  • Dermatology

Background:

  • Malignant melanomas present with a wide spectrum of cytomorphological and architectural characteristics.
  • These features can lead to differential diagnostic challenges, as melanomas may mimic other neoplastic entities such as carcinomas, sarcomas, lymphomas, and germ cell tumors.

Purpose of the Study:

  • To comprehensively review the diverse cytomorphological, architectural, and stromal features of malignant melanomas.
  • To highlight the potential for melanomas to mimic other tumors, emphasizing the importance of accurate histopathological assessment.

Main Methods:

  • Review of cytomorphological variations including cell types, nuclear features, and cytoplasmic inclusions.
  • Analysis of architectural patterns such as fasciculation, nesting, and pseudoglandular formations.

Related Experiment Videos

  • Examination of stromal changes, including myxoid or desmoplastic alterations and vascular patterns.
  • Evaluation of immunophenotypic profiles, including typical markers and aberrant expressions.

    • Main Results:

    • Melanomas display significant heterogeneity in cell morphology (e.g., pleomorphic, spindle, clear cells) and nuclear features.
    • Architectural variations are extensive, encompassing patterns like fasciculation, whorling, nesting, and pseudostratifications.
    • Stromal alterations, such as myxoid changes and hemangiopericytoma-like vasculature, are observed.
    • Immunophenotypically, melanomas are typically positive for S100 protein, NKIC3, HMB-45, Melan-A, and tyrosinase, but aberrant expression of cytokeratins, desmin, and other markers can occur.

    Conclusions:

    • The wide array of cytomorphological, architectural, and stromal features in malignant melanomas necessitates careful evaluation to avoid misdiagnosis.
    • Awareness of potential mimicry with other malignancies and benign tumors is critical for accurate diagnosis.
    • Immunohistochemistry plays a vital role in confirming the diagnosis, even in cases with aberrant phenotypes.