Related Experiment Videos
Ovarian leiomyosarcoma: an autopsy case report.
1Departments of Pathology and; Obstetrics and Gynecology, International Medical Center of Japan, Tokyo.
Pathology International
|May 3, 2000
Summary
Primary ovarian leiomyosarcoma is a rare cancer. This autopsy case highlights its aggressive nature and poor prognosis, with widespread metastasis observed post-surgery.
Area of Science:
- Gynecologic Oncology
- Pathology
- Surgical Oncology
Background:
- Primary non-specific sarcoma of the ovary is exceptionally rare.
- Pure ovarian leiomyosarcoma (LMS) has been reported in only 22 cases.
- This study details an autopsy case of a primary ovarian LMS.
Observation:
- A 73-year-old woman presented with an abdominal mass and defecation difficulty.
- Surgical tumor excision with bilateral salpingo-oophorectomy and hysterectomy was performed.
- Pathological examination confirmed pure leiomyosarcoma of the left ovary via immunohistochemistry.
Findings:
- The patient did not receive adjuvant radio-chemotherapy.
- Abdomino-pelvic sonography at 18 months revealed tumor recurrence and hepatic metastasis.
- Post-mortem examination showed extensive peritoneal, liver, lung, pancreas, gastric, muscle, and skin metastases.
Implications:
- Ovarian LMS demonstrates a poor prognosis.
- Histological indicators like mitotic activity, proliferative activity, and p53 status may influence prognosis.
- This case underscores the aggressive behavior and metastatic potential of ovarian LMS.