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Childhood pernio and cryoproteins
1Department of Dermatology,, University of Colorado School of Medicine, Denver, Colorado, USA. william.weston@exchange.UCHSC.edu
Pediatric Dermatology
|May 3, 2000
Summary
Childhood pernio, a rare skin condition, was studied in eight children. The study found it uncommon and potentially linked to cryoproteins, with symptoms resolving within three months.
Area of Science:
- Dermatology
- Pediatrics
- Immunology
Background:
- Childhood pernio is infrequently documented, primarily through case reports.
- Understanding its clinical presentation and associations in children is limited.
Purpose of the Study:
- To investigate the clinical spectrum, associations, cryoprotein presence, and evolution of childhood pernio.
- To evaluate cases of childhood pernio over a 10-year period.
Main Methods:
- Retrospective case series analysis of children diagnosed with pernio.
- Inclusion criteria: patients seen at a university ambulatory care center over 10 years.
- Data collected: cutaneous manifestations, clinical associations, cryoproteins, and long-term follow-up (≥3 years).
Main Results:
- Eight children (4 boys, 4 girls) diagnosed with pernio.
- Lesions predominantly affected fingers, toes, and ears.
- Four children tested positive for cryoglobulins or cold agglutinins; two had positive rheumatoid factor; none had positive antinuclear antibodies (ANA).
- All patients achieved complete resolution within 3 months without recurrence during follow-up.
Conclusions:
- Childhood pernio is an uncommon dermatological condition in children.
- The presence of cryoproteins (cryoglobulins, cold agglutinins) may be associated with childhood pernio.
- The condition appears to have a favorable prognosis with complete resolution.