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Degranulating eosinophils in human endometriosis.

R D Blumenthal¹, M Samoszuk, A P Taylor

¹Garden State Cancer Center, Belleville, New Jersey 07109, USA.

The American Journal of Pathology

|May 4, 2000

Summary

Degranulating eosinophils are abundant in endometriosis, suggesting they aid in tissue remodeling and wound healing, not a specific immune response to cancer. This finding uses endometriosis as a model for studying eosinophil roles.

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Area of Science:

Gynecologic pathology
Immunology
Tissue remodeling

Background:

Degranulating eosinophils are observed in endometrial cancers.
Endometriosis, a non-neoplastic endometrial tissue disorder, serves as a model to investigate eosinophil roles.
Differentiating between immune response and tissue remodeling is crucial.

Purpose of the Study:

To determine if eosinophil degranulation in endometriosis is linked to cancer-specific immunity or general tissue remodeling.
To evaluate eosinophil peroxidase and chemoattractants in normal endometrium and endometriosis.

Main Methods:

Immunohistochemistry and Western blotting were used.
Eosinophil peroxidase, a marker for eosinophil degranulation, was assessed.
Coexpression of interleukin-5 (IL-5), eotaxin, and RANTES was analyzed.

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Main Results:

Intense eosinophil peroxidase deposition was found in 21/24 endometriosis samples, primarily in fibrotic areas and blood vessels.
Normal proliferative endometrium showed no eosinophil degranulation; secretory endometrium showed only weak staining.
Degranulating eosinophils correlated with eotaxin, IL-5, and RANTES presence in endometriosis tissues.

Conclusions:

Abundant degranulating eosinophils in endometriosis fibrous regions indicate a role in general tissue remodeling and wound healing.
Eosinophil involvement appears to be a general phenomenon rather than a cancer-specific immune response.
Endometriosis provides a valuable model for understanding eosinophil functions in tissue repair.