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Isatin (Indole-2, 3-dione) inhibits natriuretic peptide-induced hyperthermia in rats
I Pataki1, A Adamik, G Telegdy
1Department of Pathophysiology, MTA-SZOTE Neurohumoral Research Group, Albert Szent-Györgyi Medical University, Semmelweis u.1, P.O. Box 531, H-6701, Szeged, Hungary.
Abstract:
The effects of an endogenous indole, isatin (indole-2, 3-dione), on the hyperthermia induced by atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32), and C-type natriuretic peptide (CNP-22) were investigated in rats. Intracerebroventricular administration of each peptide in a dose of 1 microg caused elevations in colon temperature 30 and 60 min after injection. An intraperitoneal (i.p.) injection of isatin (50 mg/kg) abolished the natriuretic peptide-induced hyperthermia. These data reinforce the possible involvement of natriuretic peptides in thermoregulatory processes in the central nervous system, and suggest that isatin might counteract their hyperthermic effect in vivo.