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Published on: October 23, 2018
Effects of oral casokefamide on plasma levels, tolerance, and intestinal transit in man
E Schulte-Frohlinde1, W Reindl, D Bierling
1Department of Medicine II, Technical University of Munich, Ismaningerstrasse 22, 81675, Munich, Germany. Ewert.Schulte-Frohlinde@lrz.tu-muenchen.de
Abstract:
Food-derived opioid peptides such as beta-casomorphins are of interest for treatment of chronic diarrhea. The beta-casomorphin analog casokefamide was administered orally at doses of 5.5, 8.0, and 16.0 mg to 10 healthy male volunteers, respectively. Dose-dependent increases of plasma levels with a maximum of 350 fmol/l were determined. No side-effects due to casokefamide has been observed. In comparison to placebo, casokefamide showed a trend toward prolongation of oro-caecal transit time. Orally applied casokefamide is well tolerated and may represent a useful tool for treatment of diarrhea in the future.
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