Related Experiment Video

Updated: Oct 16, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

Experimental topical ototoxicity investigations: can we underestimate unilateral ototoxicity because of

Whitworth1, Rybak

  • 1Southern Illinois University, School of Medicine, PO Box 19638, Springfield, IL 62794-9638, USA.

Otolaryngology and Head and Neck Surgery
|May 4, 2000
PubMed
Abstract

No abstract available in PubMed .

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Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...