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Nasal nitric oxide is not altered by topical anesthesia
W Qian1, A Graciano, J S Haight
1Zhenjiang First People's Hospital, Jiangsu, China.
American Journal of Rhinology
|May 4, 2000
Summary
Topical nasal anesthetics like lidocaine and tetracaine do not change nasal nitric oxide (NO) levels in healthy adults. This finding suggests NO measurements are reliable even after nasal anesthesia.
Area of Science:
- Otorhinolaryngology
- Respiratory Physiology
- Pharmacology
Background:
- Nasal nitric oxide (NO) is a crucial mediator in respiratory function.
- Topical anesthetics are frequently used in nasal procedures, but their effect on NO output is unknown.
Purpose of the Study:
- To investigate the impact of topical nasal anesthetic agents on nasal NO output in healthy adults.
Main Methods:
- A prospective study involving seven healthy volunteers.
- Unilateral nasal NO output was measured before and at 15 and 30 minutes after spraying lidocaine or tetracaine into one nostril, with the other nostril serving as a control.
Main Results:
- Neither lidocaine nor tetracaine significantly altered nasal NO output on the exposed side compared to baseline.
- No significant difference in NO output was observed between the anesthetic-treated and control nostrils post-administration.
- Statistical analysis showed no significant changes (P > 0.05) in NO output.
Conclusions:
- Topical anesthesia with lidocaine or tetracaine does not affect nasal NO output.
- Nasal NO measurements are likely unaffected by the use of topical nasal anesthetics.