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T-cell memory: lessons from Epstein-Barr virus infection in man
A B Rickinson1, M F Callan, N E Annels
1CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, UK. a.b.rickinson@bham.ac.uk
Abstract:
Epstein-Barr virus offers an ideal opportunity to follow the human T-cell response to a virus infection over time from its acute primary phase, as seen in infectious mononucleosis patients, into the memory phase that accompanies life-long virus persistence. Here we review recent evidence on the development and maturation of cytotoxic T-cell memory using this viral system.