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[Lymphocyte in chronic lymphatic leukemia].

G Brittinger, W Augener, K Bremer

    Blut
    |May 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Chronic lymphatic leukemia (CLL) involves abnormal B cells with reduced lysosomes and impaired responses to stimulation. These neoplastic B cells show altered circulation, impacting leukemia progression.

    Area of Science:

    • Hematology
    • Immunology
    • Cell Biology

    Context:

    • Chronic lymphatic leukemia (CLL) is a lymphoproliferative disorder characterized by the accumulation of malignant B lymphocytes.
    • Understanding the functional and morphological abnormalities of these malignant cells is crucial for elucidating CLL pathogenesis.

    Purpose:

    • To investigate the morphological and functional characteristics of lymphocytes in patients with chronic lymphatic leukemia (CLL).
    • To assess the in vitro response of CLL lymphocytes to mitogenic stimulation and their in vivo circulation kinetics.

    Summary:

    • Peripheral blood lymphocytes in CLL patients were predominantly identified as B cells with reduced cytoplasmic area and fewer lysosomes, indicating decreased lysosomal hydrolase activity.
    • CLL lymphocytes exhibited diminished or delayed responses to in vitro stimulation (PHA, PWM) with reduced cell transformation, suggesting they are morphologically and functionally abnormal neoplastic B cells.

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  • While some reactive lymphocytes may originate from normal T or B cells, neoplastic cells might also respond to mitogens. In vivo studies revealed impaired circulation and recirculation kinetics of CLL B lymphocytes, contrasting with normal T cell kinetics.

    • Impact:

    • This study highlights the significant morphological and functional deficits in CLL B lymphocytes, contributing to the understanding of the disease's cellular basis.
    • The findings suggest that CLL lymphocytes are intrinsically abnormal, impacting their behavior in circulation and response to immune stimuli.
    • Further research into these cellular abnormalities could inform therapeutic strategies targeting CLL progression.