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Updated: Aug 8, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Gas endarterectomy with distal bypass of the coronary arteries
Insights
Modified endarterectomy techniques improve outcomes for coronary artery disease. Distal endarterectomy with aortocoronary bypass shows promise in diffuse atherosclerotic involvement, broadening patient selection for myocardial revascularization.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
- Vascular Surgery
Background:
- Early carbon dioxide gas endarterectomy for total coronary artery occlusion led to progressive stenosis and reocclusion.
- Distal branches remained unaffected, suggesting a need for technique modification.
Purpose of the Study:
- To modify endarterectomy techniques for improved outcomes in coronary artery disease.
- To evaluate a new approach involving distal endarterectomy with aortocoronary bypass.
Main Methods:
- Initial technique: Full-length endarterectomy of the right coronary artery.
- Modified technique: Distal endarterectomy combined with aortocoronary bypass to the endarterectomized segment.
- Application in cases of diffuse atherosclerotic involvement of distal arterial branches.
Main Results:
- Early technique resulted in segmental stenosis and reocclusion within 36 months.
- Modified technique applied to 58 patients with a 6.9% operative mortality (associated with comorbidities).
- High patency rates observed in surviving patients with the modified technique.
Conclusions:
- The modified distal endarterectomy with aortocoronary bypass technique is effective for diffuse coronary atherosclerosis.
- This approach expands patient eligibility for direct myocardial revascularization.
- The modified technique offers a high patency rate in selected patients.
Abstract:
Carbon dioxide gas endarterectomy was first applied in cases of total occlusion of the right coronary artery. The early technique involved removal of the disease core along the entire length of the vessel. At follow-up, progressive changes were observed to cause segmental stenosis within the proximal and middle portions of the vessel which led to complete reocclusion of the artery at 36 months. In every case, however, the distal branches of the endarterectomized arteries appeared unaffected. On the basis of these results, we have modified our technique. The present treatment involves distal endarterectomy with aortocoronary bypass to the endarterectomized segment. This surgical approach is appropriated only in cases of diffuse atherosclerotic involvement of the distal arterial branches. It can be applied to any one of the three main coronary artery branches and has therefore broadened the range of patient selection for direct myocardial revascularization. The operative mortality in our series of 58 patients was 6.9 per cent (4 patients), but all deaths were associated with such aggravating factors as anerurysm formation, valve disease, and the preoperative evolution of myocardial infarction. The associated morbidity rate was 6.8 per cent; two patients had disruption of the sternal wound, and one suffered uncomplicated myocardial infarction. The fourth patient had a myocardial infarction followed by development of conduction defect and required operation for the insertion of a permanent transvenous pacemaker. To date, follow-up indicates a high patency rate among the surviving 54 patients.
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