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Levels of uric acid, urea and creatinine in Iraqi children with sickle cell disease

L M al-Naama1, E A al-Sadoon, T A al-Sadoon

  • 1Department of Biochemistry, College of Medicine University of Basrah, Iraq.

JPMA. the Journal of the Pakistan Medical Association
|May 5, 2000
PubMed

Insights

Serum uric acid levels were elevated in Iraqi children with sickle cell disease (SCD). Urea and creatinine levels were lower in SCD patients compared to controls, suggesting potential renal function changes.

Area of Science:

  • Pediatrics
  • Nephrology
  • Hematology

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder.
  • Renal complications are common in SCD patients.
  • Serum uric acid, urea, and creatinine are indicators of kidney function.

Purpose of the Study:

  • To determine serum uric acid, urea, and creatinine levels in children with SCD.
  • To compare these levels with those in healthy children.
  • To assess potential renal function alterations in pediatric SCD.

Main Methods:

  • Study conducted in Basrah, Iraq.
  • Included 65 children with SCD (Hb AS and Hb SS) aged 2-11 years.
  • Compared biochemical markers with 45 age and sex-matched healthy controls (Hb AA) using Varley's method.

Main Results:

  • Elevated serum uric acid levels were observed in SCD patients compared to controls (p < 0.0001).
  • Urea and creatinine levels were significantly lower in SCD patients (Hb SS and Hb AS) than in controls (p < 0.0001).
  • Statistical significance was high for all comparisons.

Conclusions:

  • Iraqi children with SCD exhibit elevated serum uric acid.
  • Lower urea and creatinine levels in SCD patients warrant further investigation.
  • Creatinine clearance studies are recommended to evaluate renal function in pediatric SCD.
Abstract

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