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Imipenem but not meropenem induces convulsions in DBA/2 mice, unrelated to cerebrospinal fluid concentrations
A Dupuis1, C Pariat, P Courtois
1Laboratoire de pharmacie galénique et biopharmacie, faculté de médecine & pharmacie, Poitiers, France.
Fundamental & Clinical Pharmacology
|May 5, 2000
Abstract:
Imipenem and meropenem CSF diffusion was comparable in DBA/2 mice but only imipenem induced convulsions, not related to CSF concentration.
Insights
Imipenem and meropenem showed similar cerebrospinal fluid (CSF) diffusion in mice. However, only imipenem caused convulsions, irrespective of its CSF concentration.
Area of Science:
- Pharmacology
- Neuroscience
- Infectious Diseases
Background:
- Carbapenem antibiotics like imipenem and meropenem are crucial for treating severe bacterial infections.
- Understanding their penetration into the central nervous system (CNS), specifically cerebrospinal fluid (CSF), is vital for effective treatment of CNS infections.
- Neurological side effects, such as seizures, are potential concerns with certain antibiotics.
Purpose of the Study:
- To compare the diffusion of imipenem and meropenem into the CSF of DBA/2 mice.
- To investigate the relationship between CSF concentrations of these antibiotics and the occurrence of convulsions.
Main Methods:
- DBA/2 mice were administered imipenem and meropenem.
- CSF samples were collected to measure antibiotic concentrations.
- Occurrence of convulsions was monitored in the mice.
Main Results:
- CSF diffusion of imipenem and meropenem was found to be comparable in the studied mouse model.
- Imipenem administration led to convulsions in mice.
- Convulsions induced by imipenem were not correlated with measured CSF concentrations of the antibiotic.
Conclusions:
- While both imipenem and meropenem achieve similar levels in the CSF, imipenem possesses a higher propensity to induce seizures in DBA/2 mice.
- The mechanism of imipenem-induced convulsions may not be directly related to its concentration in the CSF.
