Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human chorionic gonadotrophin for recurrent miscarriage.

J R Scott1, N Pattison

  • 1Department of Obstetrics and Gynaecology, School of Medicine, University of Auckland, Auckland, New Zealand. n.pattison@auckland.ac.nz

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What does language matter? Adopting culturally relevant family-administered delirium assessment tools in the ICU.

Intensive care medicine·2026
Same author

Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes.

IJTLD open·2024
Same author

Correction to: Characterization of host response, resorption, and strength properties, and performance in the presence of bacteria for fully absorbable biomaterials for soft tissue repair.

Hernia : the journal of hernias and abdominal wall surgery·2024
Same author

Optogenetic stimulation of striatal patches modifies habit formation and inhibits dopamine release.

Scientific reports·2021
Same author

What are the immunological and clinical implications of microchimerism?

BJOG : an international journal of obstetrics and gynaecology·2018
Same author

Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs).

Annals of intensive care·2018

Human chorionic gonadotrophin (hCG) may reduce miscarriage risk in women with recurrent miscarriages. However, current evidence is insufficient to confirm its effectiveness due to study limitations.

Area of Science:

  • Reproductive Endocrinology
  • Maternal-Fetal Medicine
  • Clinical Trial Review

Background:

  • Recurrent miscarriage may be linked to abnormal follicular phase hormone function.
  • Human chorionic gonadotrophin (hCG) is investigated for its potential role in preventing pregnancy loss.

Purpose of the Study:

  • To assess the impact of human chorionic gonadotrophin (hCG) administration in early pregnancy on miscarriage risk.
  • Focus on women with a history of recurrent miscarriages.

Main Methods:

  • Systematic review of randomized controlled trials.
  • Searched Cochrane Pregnancy and Childbirth Group trials register (last search: January 1998).
  • Included trials comparing hCG with placebo or no treatment in women with ≥2 miscarriages.

Related Experiment Videos

Main Results:

  • Four trials with 180 women were included; trial quality varied.
  • hCG administration showed a reduced risk of miscarriage (OR 0.26; 95% CI 0.14-0.52).
  • This observed effect requires cautious interpretation due to methodological weaknesses in key studies.

Conclusions:

  • Insufficient evidence exists to recommend human chorionic gonadotrophin (hCG) for preventing miscarriage in women with unexplained recurrent spontaneous miscarriage.
  • Further high-quality research is needed to establish hCG's efficacy and safety in this context.