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Related Experiment Videos

Instruments for transcervical chorionic villus sampling for prenatal diagnosis.

Z Alfirevic1

  • 1Department of Obstetrics and Gynaecology, University of Liverpool, Liverpool, UK, L69 3BX. zarko@liverpool.ac.uk

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

Small forceps may yield better chorionic villus sampling (CVS) tissue than aspiration cannulas, but are harder to use. Current evidence doesn't strongly support changing practice for experienced clinicians.

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Area of Science:

  • Obstetrics and Gynecology
  • Prenatal Diagnostics

Background:

  • Instrument choice significantly impacts chorionic villus sampling (CVS) success.
  • Maneuverability and ultrasound visibility are crucial for instrument performance.

Purpose of the Study:

  • To compare instruments for transcervical CVS.
  • Assess effects on perinatal outcomes, tissue acquisition, technical difficulty, and maternal adverse events.

Main Methods:

  • Searched Cochrane Pregnancy and Childbirth Group trials register (up to Oct 1998).
  • Included randomized trials comparing different transcervical CVS instruments.
  • Assessed eligibility and trial quality.

Main Results:

  • Small forceps increased adequate sample likelihood compared to aspiration cannulas (OR 7.29).

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  • Small forceps were more difficult to insert (OR 0.35).
  • Portex cannula use was linked to inadequate samples and difficult procedures compared to silver/aluminum cannulas.

    • Conclusions:

    • Limited evidence supports small forceps for CVS.
    • Evidence is insufficient to recommend practice changes for clinicians proficient with aspiration cannulas.