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Maternal nutrient supplementation for suspected impaired fetal growth
1Special Department of Research, Development and Research Training in Human Reproduction, UNDP/UNFPA/WHO/World Bank, World Health Organisation, Geneva 27, Switzerland, CH-1211. gulmezoglum@who.ch
Background:
One way of attempting to improve fetal growth has been nutrient supplementation for the mother when fetal growth is impaired. Different nutrients such as carbohydrates and amino acids have been suggested as treatments for impaired fetal growth.
Objectives:
The objective of this review was to assess the effects of nutrient administration for suspected fetal growth impairment on fetal growth and perinatal outcome.
Search Strategy:
We searched the Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register. Date of last search: December 1999.
Selection Criteria:
Acceptably controlled trials of nutrient administration for suspected impaired fetal growth compared to placebo or no treatment.
Data Collection And Analysis:
Trial quality was assessed.
Main Results:
Three studies involving 121 women were included. They were small and/or had methodological limitations. No difference was detected in the number of small for gestational age infants whose mothers had received nutrients compared to those who did not (relative risk for calf blood extract 0.54, 95% confidence interval (CI) 0.20 to 1.47; for glucose 1.11, 95% CI 0.64 to 1.92; for galactose 0.78, 95% CI 0.39 to 1.54.
Reviewer'S Conclusions:
There is not enough evidence to evaluate the use of nutrient therapy for suspected impaired fetal growth. The studies were too small to detect any rare adverse effects.