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Related Experiment Videos

Interventions for trichomoniasis in pregnancy.

A M Gülmezoglu1

  • 1Special Department of Research, Development and Research Training in Human Reproduction, UNDP/UNFPA/WHO/World Bank, World Health Organisation, Geneva 27, Switzerland, CH-1211. gulmezoglum@who.ch

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

Single-dose metronidazole effectively treats trichomoniasis in pregnant women, with high cure rates. However, its impact on pregnancy outcomes remains uncertain, and partner treatment may improve efficacy.

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Pharmacology

Background:

  • Trichomoniasis, caused by Trichomonas vaginalis, is a common sexually transmitted infection.
  • Its effects on pregnancy, including preterm birth and complications, require further investigation.

Purpose of the Study:

  • To evaluate the efficacy and safety of various treatments for trichomoniasis during pregnancy.

Main Methods:

  • Systematic review of randomized controlled trials from the Pregnancy and Childbirth Group and Cochrane Controlled Trials Registers.
  • Searched databases up to December 22, 1999.
  • Included one study comparing benzoylmetronidazole to placebo in pregnant women.

Main Results:

  • Benzoylmetronidazole demonstrated high parasitological cure rates (95% at 7 days, 93% at 4 weeks).

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  • Relative risk of infection was 0.11 (95% CI 0.05–0.24) for treated women.
  • Approximately 75% of sexual partners received treatment.

    • Conclusions:

    • Single-dose metronidazole is likely effective for treating trichomoniasis in pregnant individuals.
    • The effect of this treatment on pregnancy outcomes is currently unknown.
    • Improved partner treatment adherence may enhance cure rates.