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Carbohydrate supplementation of human milk to promote growth in preterm infants
1Newborn Services, National Women's Hospital, Private Bag 92 189, Auckland, New Zealand. CarlK@ahsl.co.nz
Insights
No studies evaluated carbohydrate supplements alone for preterm infant growth. Further research is needed on multicomponent fortifiers for optimal infant development.
Area of Science:
- Neonatal nutrition
- Pediatric research
Background:
- Preterm infants require specialized nutrition for optimal growth and development.
- Human milk is the preferred nutrition source, but may require supplementation.
Purpose of the Study:
- To assess if carbohydrate supplementation in human milk improves growth and neurodevelopment in preterm infants.
- To identify any adverse effects associated with carbohydrate supplementation.
Main Methods:
- A systematic literature search was conducted using standard neonatal review group strategies.
- Included randomized or quasi-random trials of carbohydrate-supplemented human milk in preterm infants.
Main Results:
- No eligible trials were identified that met the inclusion criteria.
- The absence of studies means no direct evidence exists for carbohydrate supplementation's effects.
Conclusions:
- Currently, no research specifically evaluates carbohydrate supplementation alone for improving preterm infant growth and neurodevelopment.
- Recommendations for practice cannot be made; future research should focus on multicomponent fortifiers.
Background:
This section is under preparation and will be included in the next issue.
Objectives:
The main objective was to determine if addition of carbohydrate supplements to human milk leads to improved growth and neurodevelopmental outcomes without significant adverse effects in preterm infants.
Search Strategy:
The standard search strategy of the Neonatal Review Group was used. This includes searches of the Oxford Database of Perinatal Trials, MEDLINE, previous reviews including cross references, abstracts, conferences and symposia proceedings, expert informants, journal handsearching mainly in the English language.
Selection Criteria:
All trials utilising random or quasi-random allocation evaluating the supplementation of human milk with carbohydrate in preterm infants within a nursery setting were eligible.
Data Collection And Analysis:
Not applicable.
Main Results:
No eligible trials were found.
Reviewer'S Conclusions:
There are no studies which have specifically evaluated the addition of carbohydrate alone for the purpose of improving growth and neurodevelopmental outcomes. No recommendations for practice can be made. Research should be directed towards comparison of different quantities and types of carbohydrate in multicomponent fortifiers containing protein and minerals, specifically evaluating short-term growth and long-term growth and neurodevelopmental outcomes.
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