Kinesthetic stimulation for preventing apnea in preterm infants
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Published on: April 19, 2024
D J Henderson-Smart1, D A Osborn
1NSW Centre for Perinatal Health Services Research, Queen Elizabeth II Institute for Mothers and Infants, Building DO2, University of Sydney, Sydney, NSW, Australia, 2006. dhs@mail.usyd.edu.au
Insights
Prophylactic kinesthetic stimulation using oscillating mattresses does not reduce apnea or bradycardia in preterm infants. This intervention is not recommended for clinical practice or further research in this population.
Area of Science:
- Neonatal Medicine
- Pediatric Pulmonology
- Clinical Trials
Background:
- Recurrent apnea is prevalent in preterm infants, especially those born at very early gestational ages.
- Apneic episodes can cause hypoxemia and bradycardia, potentially requiring resuscitation.
- Physical stimulation is a common method to manage breathing, with kinesthetic stimulation (e.g., oscillating mattress) explored for apnea prevention.
Purpose of the Study:
- To evaluate if prophylactic kinesthetic stimulation reduces apnea and bradycardia in preterm infants at risk.
- To determine the effect on the need for intermittent positive pressure ventilation (IPPV).
Main Methods:
- A systematic review was conducted using standard Neonatal Review Group search strategies.
- Included randomized or quasi-random trials involving preterm infants at risk for clinical apnea.
- Data were synthesized using relative risk, with separate author evaluation of trial quality and data extraction.
Main Results:
- No significant differences were observed in short-term outcomes such as apnea/bradycardia events or use of IPPV.
- No differences were found in intraventricular hemorrhage (IVH), sleep/wake cycles, or neurological status at discharge.
- Long-term effects on growth and development to one year also showed no differences in the single trial assessed.
Conclusions:
- Prophylactic kinesthetic stimulation is not recommended for reducing apnea/bradycardia in preterm infants.
- Current evidence does not support further research into the prophylactic use of kinesthetic stimulation for apnea prevention in this group.
Background:
Recurrent apnea is common in preterm infants, particularly at very early gestational ages. These episodes of loss of effective breathing can lead to hypoxemia and bradycardia, which may be severe enough to require resuscitation including use of positive pressure ventilation or other treatments. Physical stimulation is often used to restart breathing and it is possible that repeated stimulation, such as with an oscillating mattress (kinesthetic stimulation), might prevent apnea and its consequences.
Objectives:
In preterm infants at risk for apnea, does prophylactic use of kinesthetic stimulation lead to a clinically important reduction in apnea and bradycardia, and use of intemittent positive preswsure ventilation (IPPV).
Search Strategy:
The standard search strategy of the Neonatal Review Group was used. This included searches of the Oxford Database of Perinatal trials, Cochrane Controlled Trials Register, MEDLINE, previous reviews including cross references, abstracts, conferences and symposia proceedings, expert informants, journal handsearching mainly in the English language.
Selection Criteria:
All trials in preterm infants at risk of developing clinical apnea which utilised random or quasi-random allocation to treatment with an oscillating mattress or control, were eligible.
Data Collection And Analysis:
Standard methods of the Cochrane Collaboration and its Neonatal Review Group were used with separate evaluation of trial quality and data extraction by each author and synthesis of the data using relative risk.
Main Results:
There were no differences in short term effects (apnea /bradycardia, IVH, use of IPPV, sleep/wake cycles and neurological status at discharge) or longterm effects (in one trial - growth and development to one year).
Reviewer'S Conclusions:
Implications for practice. Prophylactic use of kinesthetic stimulation cannot be recommended to reduce apnea/bradycardia in preterm infants. Implications for research. There are currently no clear research questions regarding prophylactic use of kinesthetic stimulation to prevent apnea in preterm infants.
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