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Related Experiment Videos

Antiplatelet agents for preventing and treating pre-eclampsia.

M Knight1, L Duley, D J Henderson-Smart

  • 1Resource Centre for Randomised Trials, Institute of Health Sciences, Old Road, Headington, Oxford, UK, OX3 7LF. lelia.duley@ndm.ox.ac.uk

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

Antiplatelet agents, such as low dose aspirin, significantly reduce the risk of pre-eclampsia and related baby deaths. These agents offer moderate benefits for preventing pre-eclampsia, but more research is needed on optimal usage.

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Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Maternal-Fetal Medicine

Background:

  • Pre-eclampsia is linked to an imbalance in prostacyclin and thromboxane production.
  • This imbalance suggests antiplatelet agents may prevent or delay pre-eclampsia.

Purpose of the Study:

  • To evaluate the effectiveness and safety of antiplatelet agents for preventing and treating pre-eclampsia.

Main Methods:

  • Systematic review of 42 randomized trials involving over 32,000 pregnant women.
  • Included women at risk for or with established pre-eclampsia, excluding postpartum treatment.

Main Results:

  • Antiplatelet agents reduced pre-eclampsia risk by 15% (NNT 89) and baby deaths by 14% (NNT 250).
  • A small 8% reduction in preterm delivery was observed (NNT 72).

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  • No significant differences in small for gestational age babies or other outcomes.

    • Conclusions:

    • Antiplatelet agents, primarily low-dose aspirin, provide significant benefits for pre-eclampsia prevention.
    • Further research is needed to identify optimal patient selection, timing, and dosage for treatment.