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Related Experiment Videos

Magnesium supplementation in pregnancy.

M Makrides1, C A Crowther

  • 1Women's and Children's Hospital, Obstetrics and Gynaecology, University of Adelaide, 72 King William Road, North Adelaide, SA, Australia, 5006. mmakrides@medicine.adelaide.edu.au

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

Magnesium supplementation during pregnancy may reduce preterm birth and low birthweight. However, current evidence is limited due to the poor quality of most studies, requiring more high-quality research.

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Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Science
  • Perinatal Medicine

Background:

  • Many pregnant women have insufficient magnesium intake, particularly those from disadvantaged backgrounds.
  • Low magnesium levels may be linked to adverse pregnancy outcomes like fetal growth restriction and pre-eclampsia.
  • Magnesium supplementation is being investigated for its potential to improve maternal and infant health during pregnancy.

Purpose of the Study:

  • To evaluate the impact of magnesium supplementation during pregnancy on maternal, neonatal, and pediatric outcomes.
  • To synthesize evidence from randomized and quasi-randomized controlled trials on magnesium's effects in pregnancy.

Main Methods:

  • Searched the Cochrane Pregnancy and Childbirth Group trials register for relevant studies.

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  • Included randomized and quasi-randomized trials of dietary magnesium supplementation in pregnant women.
  • Assessed trial suitability and quality, with data independently extracted by two reviewers.

    • Main Results:

    • Six trials with 2637 women were included; only one was high-quality.
    • Oral magnesium before 25 weeks gestation was associated with reduced preterm birth (OR 0.71, 95% CI 0.52-0.95).
    • Benefits observed included less maternal hospitalization, fewer antepartum hemorrhages, and lower incidence of low birthweight and small-for-gestational-age infants, though bias from poor quality trials is noted.

    Conclusions:

    • The existing evidence base for magnesium supplementation in pregnancy is largely based on low-quality trials.
    • Insufficient high-quality evidence currently supports the routine use of dietary magnesium supplementation for beneficial pregnancy outcomes.
    • Further high-quality research is needed to definitively establish the efficacy and safety of magnesium supplementation during pregnancy.