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Cooling therapy for acute stroke.

M Correia1, M Silva, M Veloso

  • 1Neurology Department, Hospital Geral de Santo António, Largo Prof Abel Salazar, Porto, Portugal, 4050. nedcv@mail.telepac.pt

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
This summary is machine-generated.

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Current evidence does not support routine cooling therapy for acute stroke patients. Further randomized trials are needed to investigate the neuroprotective potential of hypothermia in stroke treatment.

Area of Science:

  • Neurology
  • Critical Care Medicine

Background:

  • Emerging research links body temperature to prognosis in acute stroke patients.
  • Fever management is a critical aspect of acute stroke care.

Purpose of the Study:

  • To evaluate the efficacy of therapeutic cooling in patients experiencing acute ischemic stroke or primary intracerebral hemorrhage.
  • To synthesize evidence from randomized controlled trials on cooling therapy for acute stroke.

Main Methods:

  • Comprehensive literature search of multiple databases (Cochrane Stroke Group, MEDLINE, EMBASE) up to November 1998.
  • Inclusion of completed randomized controlled trials and controlled clinical trials, regardless of publication status.
  • Contacting trial investigators and manufacturers for additional data on cooling interventions.

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Main Results:

  • No randomized controlled trials (RCTs) or controlled clinical trials were identified that met the inclusion criteria.
  • One placebo-controlled trial investigating the antipyretic drug metamizol is currently in progress.

Conclusions:

  • There is insufficient evidence from RCTs to recommend routine use of physical or chemical cooling for acute stroke.
  • Experimental data suggest potential neuroprotective effects of hypothermia in cerebral ischemia and improved outcomes in severe head injury.
  • Further well-designed clinical trials are warranted to explore the role of cooling therapy in acute stroke management.