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Related Experiment Videos

Bromocriptine for unexplained subfertility in women.

E Hughes1, J Collins, P Vandekerckhove

  • 1Rm HSC-4F7, Department of Obstetrics and Gynaecology, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada, L8N 3Z5. hughese@fhs.csu.mcmaster.ca

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

Bromocriptine does not improve conception rates in women with unexplained subfertility. Further research is needed, especially for those with galactorrhea.

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Area of Science:

  • Reproductive Endocrinology
  • Clinical Trial Analysis

Background:

  • Bromocriptine is known to treat hyperprolactinemic amenorrhea.
  • Its potential benefit for unexplained subfertility in women warrants investigation.

Purpose of the Study:

  • To evaluate the efficacy of bromocriptine in treating unexplained subfertility in women.

Main Methods:

  • Systematic review of randomized controlled trials from the Cochrane Subfertility Review Group.
  • Inclusion criteria: bromocriptine vs. placebo or no treatment for unexplained subfertility.
  • Data extraction and quality assessment by two independent reviewers.

Main Results:

  • Three double-blind, placebo-controlled trials with 127 women were analyzed.

Related Experiment Videos

  • Bromocriptine treatment did not significantly improve conception rates compared to placebo (OR 1.12, 95% CI 0.48-2.57).

    • Conclusions:

    • Insufficient evidence exists to support bromocriptine use for unexplained subfertility.
    • Further trials may be beneficial for women with unexplained subfertility and co-existing galactorrhea.