Bromocriptine for unexplained subfertility in women

Bromocriptine improves hyperprolactinemic amenorrhea and so could also be helpful in the treatment of unexplained subfertility in women.

To assess the effects of bromocriptine in women with unexplained subfertility.

The Cochrane Subfertility Review Group specialised register of controlled trials was searched.

Randomised trials comparing bromocriptine with placebo or no treatment in women with unexplained subfertility.

Two reviewers applied the eligibility criteria and assessed trial quality independently.

Three trials involving of 127 women were included. All trials were double-blind comparisons with placebo, and one was of crossover design. Conception rates with bromocriptine treatment did not improve compared with placebo (odds ratio was 1.12, 95% confidence interval 0.48 to 2.57).

There is not enough evidence to evaluate bromocriptine use in women with unexplained subfertility. However trials for women with unexplained subfertility who also have expressible galactorrhea may be worthwhile.