Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interventions for treating schistosomiasis haematobium.

N Squires1

  • 1Department for International Development, 94 Victoria Street, London, U K, SW1E 5JL. n-squires@dfid.gtnet.gov.uk

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

Praziquantel (single dose) shows higher cure rates for urinary schistosomiasis (Schistosomiasis haematobium) than metrifonate (split dose). However, both treatments have high reinfection rates, necessitating further research for Schistosomiasis haematobium.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The global state of disease surveillance and delivering the Pandemic Accord.

Public health·2024
Same author

Building the evidence base for Integrated Disease Surveillance as a tool for strengthened health security.

Public health·2023
Same author

Will lessons from the global COVID-19 response strengthen commitment to sustainable development?

Perspectives in public health·2021
Same author

Dysphagia management for progressive neurological conditions.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2006
Same author

School and neuropsychological performance of evacuated children in Kyiv 11 years after the Chornobyl disaster.

Journal of child psychology and psychiatry, and allied disciplines·2000
Same author

Promoting health in prisons.

BMJ (Clinical research ed.)·1996

Area of Science:

  • Tropical Medicine
  • Parasitology
  • Clinical Pharmacology

Background:

  • Schistosomiasis haematobium is a parasitic disease transmitted by freshwater snails, primarily affecting the urinary tract.
  • This review focuses on urinary schistosomiasis, distinguishing it from intestinal schistosomiasis.

Purpose of the Study:

  • To evaluate the efficacy of different drug treatments for Schistosomiasis haematobium.
  • To compare praziquantel and metrifonate in treating urinary schistosomiasis.

Main Methods:

  • Systematic review of randomized controlled trials identified through Cochrane Infectious Diseases Group, Medline, and WHO contacts.
  • Inclusion criteria focused on trials evaluating metrifonate, praziquantel, or other drugs for Schistosomiasis haematobium.
  • Trial quality assessment and data extraction were performed by one reviewer and verified by an editor.

Related Experiment Videos

Main Results:

  • Five trials conducted in Africa were included, with variable quality.
  • Praziquantel (40 mg/kg) demonstrated superior parasitological cure rates compared to single-dose metrifonate (10 mg/kg).
  • Both drugs improved nutritional status and physical fitness, with no significant difference in clinical outcomes like cessation of haematuria.

Conclusions:

  • Single-dose praziquantel appears more effective for parasitological cure of Schistosomiasis haematobium than split-dose metrifonate.
  • High reinfection rates were observed with both praziquantel and metrifonate treatments.
  • Further research is needed to address the high reinfection rates associated with current treatments.