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Related Experiment Videos

Garlic for peripheral arterial occlusive disease.

R G Jepson1, J Kleijnen, G C Leng

  • 1NHS Centre for Reviews and Dissemination, University of York, Heslington, York, UK, YO1 5DD. ruthj@ibm.net

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

Garlic supplements did not significantly improve walking distance in patients with peripheral arterial occlusive disease. A single trial found no benefits for atherosclerosis progression or related symptoms.

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Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Medical Nutrition

Background:

  • Garlic preparations are commercially available and suggested to benefit atherosclerosis risk factors.
  • Peripheral arterial occlusive disease (PAOD) is a manifestation of atherosclerosis.

Purpose of the Study:

  • To review the efficacy of dried and non-powdered garlic preparations in treating peripheral arterial occlusive disease.
  • To assess garlic's impact on objective and subjective measures of lower limb atherosclerosis progression.

Main Methods:

  • Searched multiple databases (Cochrane, AMED, EMBASE, BIDS ISI) and contacted experts for relevant randomized trials up to August 1998.
  • Included one randomized trial with 78 participants (aged 40-75) treated for 12 weeks.
  • Extracted data and assessed trial quality independently, contacting investigators for missing information.

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Main Results:

  • After 12 weeks, pain-free walking distance showed no statistically significant difference between the garlic and placebo groups.
  • No significant differences were observed in blood pressure, heart rate, or ankle/brachial pressures.
  • A noticeable garlic odor was reported by more patients in the garlic group (28%) compared to the placebo group (12%).

Conclusions:

  • A single, short-duration trial indicated no improvement in walking distance for peripheral arterial occlusive disease patients using garlic.
  • The study found no evidence that garlic therapy impacts atherosclerosis progression or related clinical outcomes in the short term.