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Related Experiment Videos

Silver acetate for smoking cessation.

T Lancaster1, L F Stead

  • 1ICRF General Practice Research Group, Division of Public Health and Primary Health Care, Institute of Health Sciences, Old Road, Headington, Oxford, UK, OX3 7LF. tim.lancaster@dphpc.ox.ac.uk

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
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Silver acetate, used to deter smoking, shows little evidence of effectiveness in helping people quit. Studies indicate its potential benefit is minimal compared to nicotine replacement therapy.

Area of Science:

  • Addiction Medicine
  • Pharmacology
  • Public Health

Background:

  • Silver acetate is marketed as a smoking cessation aid by creating an unpleasant taste.
  • It aims to extinguish smoking urges by pairing them with an aversive stimulus.

Purpose of the Study:

  • To evaluate the effectiveness of silver acetate products in promoting smoking cessation.
  • This review focused on gum, lozenge, and spray formulations.

Main Methods:

  • Conducted a systematic review of randomized controlled trials.
  • Included studies with at least six months of follow-up for smoking status.
  • Performed meta-analysis where appropriate, counting lost participants as smokers.

Main Results:

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  • Two studies provided long-term data comparing silver acetate to placebo.
  • The odds ratio for quitting with silver acetate versus placebo was 1.05 (95% CI: 0.63–1.73).
  • One study included a nicotine gum arm for comparison.

Conclusions:

  • Current evidence suggests limited specific efficacy of silver acetate for smoking cessation.
  • Observed effects are likely smaller than those of nicotine replacement therapy.
  • Poor compliance may contribute to the lack of observed effect.