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Interventions for treating trichomoniasis in women
1Special Department of Research, Development and Research Training in Human Reproduction, UNDP/UNFPA/WHO/World Bank, World Health Organisation, Geneva 27, Switzerland, CH-1211. gulmezoglum@who.ch
The Cochrane Database of Systematic Reviews
|May 5, 2000
Summary
Single oral doses of nitroimidazoles effectively treat trichomoniasis in women. Partner treatment is crucial for preventing reinfection and reducing the prevalence of this common sexually transmitted infection.
Area of Science:
- Infectious Diseases
- Public Health
- Women's Health
Background:
- Trichomoniasis, caused by Trichomonas vaginalis, affects approximately 120 million women globally each year.
- This sexually transmitted infection is linked to an increased risk of HIV transmission.
- Effective treatment strategies are essential for managing the widespread impact of trichomoniasis.
Purpose of the Study:
- To evaluate the efficacy of diverse treatment strategies for trichomoniasis in women.
- To assess the impact of different antitrichomonal drugs and dosages.
- To synthesize evidence from randomized and quasi-randomized controlled trials.
Main Methods:
- Comprehensive literature search of major databases (Cochrane, MEDLINE, EMBASE) and other sources.
- Inclusion of published data from randomized or quasi-randomized trials involving women with trichomoniasis.
- Independent quality assessment and data extraction by two reviewers.
Main Results:
- Fifty-two trials were included in the review.
- Nitroimidazoles demonstrated effectiveness in achieving short-term parasitological cure.
- Treating sexual partners significantly reduced long-term reinfection rates.
Conclusions:
- A single oral dose of nitroimidazoles can achieve parasitological cure.
- Developing effective partner treatment strategies is vital to prevent reinfection.
- Further research should aim to reduce the overall prevalence of trichomoniasis.