Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nedocromil sodium for preventing exercise-induced bronchoconstriction.

C H Spooner1, L D Saunders, B H Rowe

  • 1Institute of Health Economics, No. 710, 10665 Jasper Avenue, Edmonton, Alberta, Canada, T5J 3S9. cspooner@ihe.ab.ca

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

A single dose of nedocromil sodium effectively prevents exercise-induced bronchoconstriction by reducing the severity and duration of symptoms. This medication is particularly beneficial for individuals with more severe exercise-induced asthma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Workers' recovery from concussions presenting to the emergency department.

Occupational medicine (Oxford, England)·2019
Same author

Adherence to osteoporosis therapy after an upper extremity fracture: a pre-specified substudy of the C-STOP randomized controlled trial.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

Inhaled short-acting bronchodilators for managing emergency childhood asthma: an overview of reviews.

Allergy·2016
Same author

Understanding fragility fracture patients' decision-making process regarding bisphosphonate treatment.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2016
Same author

Factors associated with hospital admission following asthma exacerbations: a systematic review - ERRATUM.

CJEM·2016
Same author

Air pollution and emergency department visits for epistaxis.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2014

Area of Science:

  • Pulmonology
  • Pharmacology
  • Exercise Physiology

Background:

  • Exercise-induced bronchoconstriction (EIB) manifests as cough, dyspnea, wheeze, and chest tightness.
  • Current management strategies include pre-exercise pharmacotherapy with beta2-agonists and non-steroidal anti-inflammatory agents like cromones.

Purpose of the Study:

  • To evaluate the efficacy of a single dose of nedocromil sodium in preventing exercise-induced bronchoconstriction.

Main Methods:

  • A systematic review of randomized controlled trials comparing single-dose nedocromil sodium with placebo.
  • Searches included major trial registers, current contents, and reference lists; drug manufacturer and author contact facilitated citation retrieval.
  • Trial quality assessment and data extraction were performed independently by two reviewers.

Related Experiment Videos

Main Results:

  • Twenty randomized controlled trials involving 280 participants were analyzed.
  • Nedocromil sodium (4 mg inhaled) significantly improved the maximum fall in forced expiratory volume in one second (FEV1) by 15.6% (95% CI: 13.2 to 18.1) compared to placebo.
  • The drug reduced recovery time to normal lung function from over 30 minutes to under 10 minutes, with greater effects observed in severe EIB cases. No significant adverse effects were reported.

Conclusions:

  • Pre-exercise administration of nedocromil sodium effectively mitigates the severity and duration of exercise-induced bronchoconstriction.
  • The therapeutic benefit is more pronounced in individuals experiencing severe exercise-induced bronchoconstriction.