Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Zotepine for schizophrenia.

M Fenton1, S Morris, P De-Silva

  • 1Trent Ward, South Tees Community and Mental Health Services Trust, St Lukes Hospital, Marton Road, Middlesborough, Cleveland, UK, TS4 3EE. rsmor@globalnet.co.uk

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The brain under pressure: Exploring neurophysiological responses to cognitive stress.

Brain and cognition·2024
Same author

Publisher's Note: "Reducing control noise in gravitational wave detectors with interferometric local damping of suspended optics" [Rev. Sci. Instrum. 94, 054501 (2023)].

The Review of scientific instruments·2023
Same author

Reducing control noise in gravitational wave detectors with interferometric local damping of suspended optics.

The Review of scientific instruments·2023
Same author

Goal-directed fluid therapy using uncalibrated pulse contour analysis and balanced crystalloid solutions during hip revision arthroplasty: a quality implementation project.

Journal of orthopaedic surgery and research·2023
Same author

Sensors and actuators for the advanced LIGO A+ upgrade.

The Review of scientific instruments·2023
Same author

Structured ternary fluids as nanocrystal incubators for enhanced crystallization control.

Chemical science·2022

Zotepine shows promise as an atypical antipsychotic, potentially offering benefits over typical drugs for schizophrenia. Further research is needed to confirm its long-term effectiveness and safety.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Typical antipsychotics are standard for schizophrenia.
  • Atypical antipsychotics, like zotepine, are emerging treatments.
  • Zotepine is a dopamine antagonist with potential efficacy for negative symptoms.

Purpose of the Study:

  • To evaluate zotepine's effects against placebo, typical, and other atypical antipsychotics.
  • To assess zotepine's efficacy and safety in treating schizophrenia and related psychoses.

Main Methods:

  • Conducted comprehensive electronic literature searches (1980-1999).
  • Included all randomized clinical trials comparing zotepine to other treatments.
  • Extracted and analyzed data, excluding studies with >50% loss to follow-up.

Related Experiment Videos

Main Results:

  • Zotepine appears as effective as typical antipsychotics in short-term trials (4-12 weeks).
  • Zotepine showed a statistically significant improvement in mental state compared to other active drugs (RR 0.8, NNT 7).
  • Zotepine may have fewer movement disorder side effects than typical antipsychotics, with no clear differences from other atypicals.

Conclusions:

  • Zotepine could be a valuable atypical antipsychotic option.
  • More data from existing and new long-term trials are essential to validate findings.
  • Clinical use of zotepine requires further evidence beyond short-term studies.