Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beta-sitosterols for benign prostatic hyperplasia.

T Wilt1, A Ishani, R MacDonald

  • 1General Internal Medicine, Department of Veterans Affairs Coordinating Center of the, One Veterans Drive, Minneapolis, Minnesota 55417, USA. wilt.timothy@minneapolis.va.gov

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fourier-transform-spectroscopic photoabsorption cross sections and oscillator strengths for the S<sub>2</sub> BΣu-3-XΣg-3 system.

The Journal of chemical physics·2018
Same author

Predissociation of the B Σu-3 state of S<sub>2</sub>: A coupled-channel model.

The Journal of chemical physics·2018
Same author

Observation of a new electronic state of CO perturbing W ¹Π(v=1).

The Journal of chemical physics·2014
Same author

Orientation of the porphyrin ring in artificial chlorophyll membranes.

The Journal of membrane biology·2013
Same author

The transport of potassium through lipid bilayer membranes by the neutral carriers valinomycin and monactin : Experimental studies to a previously proposed model.

The Journal of membrane biology·2013
Same author

Measurement of a stranger's influence on the behaviour of young children with their mothers.

Journal of child psychology and psychiatry, and allied disciplines·2013
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Beta-sitosterols (B-sitosterol) significantly improve urinary symptoms and flow measures in men with benign prostatic hyperplasia (BPH). Further research is needed to confirm long-term safety and effectiveness.

Area of Science:

  • Urology
  • Pharmacology
  • Natural Products

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men, causing lower urinary tract symptoms.
  • Phytosterols, including beta-sitosterols, are plant compounds with potential therapeutic benefits.

Purpose of the Study:

  • To systematically review the efficacy of beta-sitosterols in improving urinary symptoms and flow in men with BPH.
  • To compare beta-sitosterols with placebo and other BPH medications.

Main Methods:

  • Systematic review and meta-analysis of 4 randomized, placebo-controlled, double-blind trials involving 519 men.
  • Included studies assessed urologic symptom scales, nocturia, and urodynamic measurements.
  • Data extraction and analysis performed by at least two independent reviewers.

Related Experiment Videos

Main Results:

  • Beta-sitosterols significantly improved International Prostate Symptom Score (IPSS) by -4.9 points.
  • Improvements were observed in peak urine flow (WMD 3.91 ml/sec) and reduced residual urine volume (WMD -28.62 ml).
  • Non-glucosidic beta-sitosterols showed efficacy; prostate size was not reduced. Withdrawal rates were similar to placebo.

Conclusions:

  • Non-glucosidic beta-sitosterols are effective in improving urinary symptoms and flow measures in men with BPH.
  • Long-term effectiveness, safety, and complication prevention require further investigation.