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[Multiple pseudoxanthomatour rheumatoid nodules].

K Hirohata, F Ishida

    Zeitschrift Fur Rheumatologie
    |March 1, 1975
    PubMed
    Summary
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    Two rheumatoid arthritis cases presented with multiple subcutaneous nodules, mimicking pseudoxanthomatour rheumatoid nodules. Both cases showed vasculitis and high rheumatoid factor titers, with cystic activities in nodules.

    Area of Science:

    • Rheumatology
    • Dermatology
    • Pathology

    Background:

    • Rheumatoid arthritis (RA) can present with extra-articular manifestations, including subcutaneous nodules.
    • Pseudoxanthomatour rheumatoid nodules are a rare variant, characterized by specific histopathological features.
    • The temporal relationship between nodule formation and joint involvement in RA can vary.

    Purpose of the Study:

    • To describe two cases of rheumatoid arthritis associated with multiple subcutaneous nodules.
    • To highlight the clinical and pathological similarities to previously reported pseudoxanthomatour rheumatoid nodules.
    • To discuss the varied presentation of nodule formation in relation to arthritis onset.

    Main Methods:

    • Case report presentation of two patients with rheumatoid arthritis and subcutaneous nodules.

    Related Experiment Videos

  • Clinical assessment of joint involvement and nodule characteristics.
  • Laboratory investigations including rheumatoid factor titers.
  • Histopathological examination of subcutaneous nodules, noting cystic activities and vasculitis.

    • Main Results:

    • Two cases of rheumatoid arthritis with multiple subcutaneous nodules were identified.
    • Case 1: Nodules preceded asymmetrical joint involvement by 5 years.
    • Case 2: Arthritis onset preceded nodule formation.
    • Both cases exhibited circumscript vasculitis and high rheumatoid factor titers.
    • Cystic activities were observed in several nodules.

    Conclusions:

    • Subcutaneous nodules in rheumatoid arthritis can mimic pseudoxanthomatour rheumatoid nodules.
    • The onset of nodules can precede, coincide with, or follow the development of arthritis.
    • The presence of vasculitis and high rheumatoid factor titers are significant findings in these cases.