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Related Experiment Videos

Gabapentin for drug-resistant partial epilepsy.

A G Marson1, Z A Kadir, J L Hutton

  • 1University Department of Neurological Science, The University of Liverpool, The Walton Centre for Neurology & Neurosurgery, Lower Lane, Fazakerley, Liverpool, Merseyside, UK, L9 7LJ. TMarson@compuserve.com

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
This summary is machine-generated.

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Gabapentin shows efficacy as an add-on treatment for drug-resistant partial epilepsy, improving seizure frequency. However, long-term effectiveness and use in other epilepsy types require further investigation.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Up to 30% of epileptic patients develop drug-resistant epilepsy, particularly those with partial seizures.
  • Gabapentin is an antiepileptic drug investigated for add-on therapy in such cases.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of gabapentin as an add-on treatment for drug-resistant partial epilepsy.

Main Methods:

  • Systematic review of randomized, placebo-controlled, double-blind add-on trials of gabapentin.
  • Searched Cochrane Epilepsy Group trials register and contacted manufacturers/experts.
  • Assessed seizure frequency reduction, treatment withdrawal, and side effects.

Main Results:

  • Four trials involving 750 patients were included.

Related Experiment Videos

  • Gabapentin significantly increased the odds of a ≥50% seizure frequency reduction (OR 2.22).
  • Efficacy increased with dose; 1800mg showed a 28.5% response rate (NNT 6.7). Dizziness, fatigue, and somnolence were significantly associated with gabapentin.

    • Conclusions:

    • Gabapentin demonstrates efficacy as an add-on therapy for drug-resistant partial epilepsy.
    • Current evidence is based on short-term trials, with no data on long-term efficacy.
    • Findings are not generalizable to monotherapy or other epilepsy types.