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Related Experiment Videos

Serenoa repens for benign prostatic hyperplasia.

T Wilt1, A Ishani, G Stark

  • 1General Internal Medicine (111-0), Minneapolis VA/VISN 13 Center for Chronic Diseases Outcomes Research, One Veterans Drive, Minneapolis, Minnesota 55417, USA. MACDONALD.RODERICK@minneapolis.va.gov

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
This summary is machine-generated.

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Serenoa repens effectively improves urinary symptoms and flow in men with Benign Prostatic Hyperplasia (BPH) compared to placebo. It shows comparable results to finasteride with fewer adverse events, though long-term effects remain unknown.

Area of Science:

  • Urology
  • Pharmacology
  • Evidence-based Medicine

Background:

  • Benign Prostatic Hyperplasia (BPH) is a common condition in aging men.
  • Effective and safe treatment options for BPH are continuously sought.

Purpose of the Study:

  • To systematically review the efficacy and safety of Serenoa repens for BPH treatment.
  • To compare Serenoa repens with placebo and finasteride in managing BPH symptoms.

Main Methods:

  • Systematic review of 18 randomized controlled trials involving 2939 men with BPH.
  • Included double-blinded trials assessing urologic symptom scales, nocturia, and urodynamic measurements.
  • Data extraction and analysis by independent reviewers.

Main Results:

Related Experiment Videos

  • Serenoa repens significantly improved urinary symptom scores, nocturia, and peak urine flow compared to placebo.
  • It demonstrated comparable efficacy to finasteride for urinary symptoms and flow.
  • Adverse effects were mild and infrequent, with lower withdrawal rates than finasteride.

Conclusions:

  • Serenoa repens is effective in improving urologic symptoms and flow measures in BPH patients.
  • It offers a favorable safety profile compared to finasteride.
  • Long-term effectiveness and safety data are still needed.