Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Neonatal screening for sickle cell disease.

C M Lees¹, S Davies, C Dezateux

¹Evidence Based Child Health Unit, Institute of Child Health, Royal Liverpool Children's Hospital, Eaton Rd, Liverpool, UK, L12 2AP. cmlees@liverpool.ac.uk

The Cochrane Database of Systematic Reviews

|May 5, 2000

Summary

Neonatal screening for sickle cell disease lacks trial evidence. Early treatment, enabled by screening, shows benefits, suggesting screening

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Regional differences in the frequency of the c.985A>G ACADM mutation: findings from a meta-regression of genotyping and screening studies.

Clinical genetics·2013

Same author

Using cohort studies in lifecourse epidemiology.

Public health·2012

Same author

Sex and ethnic differences in the waist circumference of 5-year-old children: findings from the Millennium Cohort Study.

International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity·2010

Same author

A Case of Milky Hydrocele.

British medical journal·2010

Same author

A Case of Rhinoscleroma.

British medical journal·2010

Same author

Effect of peroxisome proliferators and inducers of xenobiotic metabolism on marker enzyme activities in cultured rat liver slices.

Toxicology in vitro : an international journal published in association with BIBRA·2010

Area of Science:

Medical screening
Genetic disorders
Public health

Background:

Sickle cell disease (SCD) is an inherited blood disorder with high incidence in malaria-endemic regions.
Early diagnosis and treatment of SCD can significantly reduce morbidity and mortality.
Neonatal screening offers a pathway for early detection before symptom onset.

Purpose of the Study:

To evaluate evidence on the effectiveness of neonatal screening for sickle cell disease compared to symptomatic diagnosis.
To assess whether screening reduces adverse outcomes in detected cases and avoids harm in the screened population.

Main Methods:

Searched Cochrane Cystic Fibrosis and Genetic Disorders Group trials register and contacted experts.
Included randomized or pseudorandomized trials comparing screening to clinical diagnosis.
Most recent search conducted in November 1999.

Main Results:

No randomized controlled trials (RCTs) of neonatal screening for sickle cell disease were identified.
The search yielded no empirical data from trials on the benefits or harms of screening.

Conclusions:

A significant lack of trial evidence exists for neonatal screening of sickle cell disease.
Non-trial literature and economic analyses suggest screening is appropriate.
Healthcare providers should consider existing evidence on early interventions like penicillin prophylaxis and vaccination when making screening decisions.

Related Experiment Videos