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Related Experiment Videos

Verifying the stroke-free phenotype by structured telephone interview.

J F Meschia1, T G Brott, F E Chukwudelunzu

  • 1Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.

Stroke
|May 8, 2000
PubMed
Summary
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A quick telephone interview effectively identifies individuals free from stroke, crucial for genetic studies. This efficient method ensures high confidence in determining stroke-free status for research participants.

Area of Science:

  • Genetics and Neurology
  • Epidemiological Research Methods

Background:

  • Genetic factors contribute to ischemic stroke risk, as supported by various study designs.
  • Sibling pair linkage studies necessitate accurate identification of stroke-free individuals to determine discordancy.

Purpose of the Study:

  • To design and validate a structured telephone interview for verifying the stroke-free phenotype.
  • To assess the efficiency and accuracy of a brief questionnaire in identifying individuals without a history of stroke.

Main Methods:

  • A structured, 8-item telephone questionnaire was administered by a coordinator unaware of medical records.
  • The interview targeted 70 outpatients over 60 years, inquiring about sudden onset neurological deficits.
  • Interview results were compared against a benchmark of systematic medical record reviews.

Related Experiment Videos

Main Results:

  • The interview, lasting 5 minutes or less, demonstrated high completion rates.
  • A positive response to any questionnaire item significantly correlated with identified stroke or transient ischemic attack (TIA) in medical records (P<0.001).
  • The interview achieved a sensitivity of 1.0 and a negative predictive value of 1.0, indicating high accuracy in identifying stroke-free individuals.

Conclusions:

  • The developed telephone interview instrument efficiently identifies stroke-free individuals with high confidence.
  • This tool is particularly suitable for verifying stroke discordancy in large-scale, multicentered sibling-pair genetic studies.