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Related Experiment Videos

Extremely low frequency magnetic fields can either increase or decrease analgaesia in the land snail depending on

F S Prato1, M Kavaliers, A W Thomas

  • 1Lawson Research Institute, University of Western Ontario, Canada. prato@lri.stjosephs.london.on.ca

Bioelectromagnetics
|May 8, 2000
PubMed
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Extremely low frequency (ELF) magnetic fields influence opioid-mediated pain relief in snails, aligning with Lednev

Area of Science:

  • Biophysics
  • Neuroscience
  • Pain Research

Background:

  • Opioid peptide-mediated antinociception is influenced by extremely low frequency (ELF) magnetic fields.
  • Prior research suggests a resonance mechanism, not induced currents or magnetite, underlies these ELF magnetic field effects.

Purpose of the Study:

  • To investigate the effects of ELF magnetic fields on endogenous opioid-mediated analgesia in the land snail, Cepaea nemoralis.
  • To test the applicability of Lednev's parametric resonance model (PRM) to ELF magnetic field interactions with ion channels involved in analgesia.

Main Methods:

  • Exposure of land snails (Cepaea nemoralis) to specific parameters of ELF magnetic fields (141-414 microT peak).
  • Assessment of changes in endogenous opioid-mediated analgesia under varying magnetic field conditions.

Related Experiment Videos

  • Investigation of the role of potassium (K+) ions using a K+ channel blocker (glibenclamide).
  • Evaluation of light dependency for observed magnetic field effects.

    • Main Results:

    • ELF magnetic fields, tuned to calcium ion (Ca2+) parameters of the PRM, modulated opioid-mediated analgesia (reduction, no effect, or increase).
    • ELF magnetic fields, tuned to potassium ion (K+) parameters of the PRM, increased opioid-mediated analgesia.
    • Increased analgesia was antagonized by glibenclamide, suggesting K+ channel involvement.
    • All observed effects were dependent on the presence of light, being absent in darkness.

    Conclusions:

    • The findings support Lednev's parametric resonance model (PRM) for ion cyclotron resonance in explaining ELF magnetic field effects on opioid-mediated analgesia.
    • Ion-specific resonance mechanisms, particularly involving Ca2+ and K+ ions, are implicated in the biological effects of ELF magnetic fields.
    • Light plays a crucial role in mediating the observed bioeffects of ELF magnetic fields on analgesia.