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Genetics, genomics, and drug discovery.

T Harris1

  • 1Structural GenomiX, 10505 Roselle Street, San Diego, CA 92121, USA. tim@stromix.com

Medicinal Research Reviews
|May 8, 2000
PubMed
Summary

Genetics and genomics are revolutionizing drug discovery and medicine. Advances in gene mapping, sequencing, and protein studies are accelerating the identification of disease genes and drug targets, though data integration remains a challenge.

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Area of Science:

  • Genomics and Genetics
  • Pharmacogenetics
  • Drug Discovery
  • Biochemistry

Background:

  • Genetics and genomics are transforming drug discovery and medical practice.
  • The human genome sequence and advanced genetic mapping techniques are key enablers.

Purpose of the Study:

  • To outline how advancements in genetics and genomics are impacting drug discovery and medicine.
  • To highlight the role of new technologies in identifying disease genes and understanding biological functions.

Main Methods:

  • Genetic mapping and positional cloning for disease allele identification.
  • Comparative sequencing for single nucleotide polymorphism (SNP) discovery.
  • Gene expression arrays and model organism studies for gene function analysis.
  • High-throughput protein structure determination for functional insights.

Main Results:

  • Accelerated identification of disease susceptibility genes and alleles.
  • Enhanced progress in pharmacogenetics through SNP discovery.
  • Improved understanding of gene function and product interactions.
  • Detailed biochemical insights into protein function.

Conclusions:

  • Genomic technologies are fundamentally altering drug discovery and medical practice.
  • Integration of diverse biological data presents the primary challenge for future progress.

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