Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Biosphonates in oncology].

B Paule1, D Clerc, N Brion

  • 1Service de Rhumatologie, Hôpital de Bicêtre, Le Kremlin Bicêtre.

Presse Medicale (Paris, France : 1983)
|May 8, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Closed-wound negative pressure therapy dressing after loop ostomy closure: a retrospective comparative study.

Scientific reports·2022
Same author

Spigelian hernia: current approaches to surgical treatment-a review.

Hernia : the journal of hernias and abdominal wall surgery·2021
Same author

Monoculture-based consumer-resource models predict species dominance in mixed batch cultures of dinoflagellates.

Harmful algae·2020
Same author

Recurrent perineal hernia repair: perineal approach - a video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
Same author

Author response to: Comment on: Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery.

The British journal of surgery·2020
Same author

Perineal hernia repair - a video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2019
Same journal

Predictive analytics and risk stratification models in internal medicine: from risk scores to real-time machine learning.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in skin disease therapeutics: from drug discovery to personalized treatment pathways.

Presse medicale (Paris, France : 1983)·2026
Same journal

AI in clinical diagnostics in dermatology: applications, validation, and real-world use cases.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in medical research and publishing: progress, risks, and future perspectives.

Presse medicale (Paris, France : 1983)·2026
Same journal

Ethical, legal, and regulatory challenges in AI-based healthcare tools.

Presse medicale (Paris, France : 1983)·2026
Same journal

Decision-making for clinicians.

Presse medicale (Paris, France : 1983)·2026
See all related articles

Bisphosphonates effectively treat cancer-related bone issues by inhibiting osteoclasts. Clinical trials show their efficacy in reducing pain and fractures, with potential survival benefits for myeloma patients.

Area of Science:

  • Oncology
  • Pharmacology
  • Bone Biology

Background:

  • Tumor-induced osteolysis, or lytic bone disease, is driven by osteoclast activation.
  • Bisphosphonates are a class of drugs known to inhibit bone resorption.
  • Osteoclasts play a critical role in bone remodeling and pathological bone destruction.

Purpose of the Study:

  • To review the efficacy of bisphosphonates in managing skeletal complications associated with cancer.
  • To highlight the role of bisphosphonates in reducing pain and preventing fractures in patients with bone metastases.
  • To discuss the potential survival benefits and future directions for bisphosphonate therapy in oncology.

Main Methods:

  • Review of clinical trial data on bisphosphonate efficacy.
  • Analysis of bisphosphonates' mechanism of action in inhibiting osteoclast activity.

Related Experiment Videos

  • Evaluation of patient outcomes in multiple myeloma and breast cancer with bone metastases.

    • Main Results:

    • Bisphosphonates are effective in treating cancer-related hypercalcemia.
    • Clinical trials demonstrate bisphosphonates reduce bone pain, pathological fractures, and spinal cord compression.
    • Pamidronate shows potential survival benefits in advanced myeloma patients, meriting further investigation.

    Conclusions:

    • Bisphosphonates are crucial in managing bone metastases and associated complications.
    • More potent bisphosphonates like zoledronate and ibandronate are being investigated.
    • The future goal is to utilize bisphosphonates to prevent the development of bone metastases.