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Renal function in the diabetic pregnant rats
M G Marina-Prendes1, A Zuccollo, O L Catanzaro
1Facultad de Farmacia y Bioquímica, Cátedra de Fisiología, Universidad de Buenos Aires.
Acta Physiologica, Pharmacologica Et Therapeutica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y [De] La Asociacion Latinoamericana De Farmacologia
|May 8, 2000
Summary
Diabetic pregnancy increases the kallikrein-kinin system and albumin excretion, indicating renal damage. However, the vasodilator system may protect the fetus despite impaired renal hemodynamics.
Area of Science:
- Nephrology
- Endocrinology
- Physiology
Background:
- Diabetic nephropathy is linked to higher urinary albumin and lower kallikrein.
- The renal kallikrein-kinin system's role in diabetic hyperfiltration is under investigation.
Purpose of the Study:
- To investigate the kallikrein-kinin system and albumin excretion during diabetic pregnancy in rats.
- To understand the impact of diabetic pregnancy on renal hemodynamics and protective mechanisms.
Main Methods:
- Wistar rats were used, divided into control and diabetic groups.
- Measurements of urinary albumin and kallikrein were taken at specific time points during and after pregnancy.
Main Results:
- The kallikrein-kinin system progressively increased in diabetic-pregnant rats but remained below control pregnancy levels.
- Albumin excretion showed significant and progressive renal damage in the diabetic state.
- Diabetic pregnancy led to impaired renal hemodynamics.
Conclusions:
- Diabetic pregnancy alters renal hemodynamics and affects the kallikrein-kinin system.
- The body may modulate the vasodilator system during diabetic pregnancy to protect the fetus.
- Further research is needed to clarify the protective role of the vasodilator system.