Related Experiment Video
Updated: Jul 2, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 26, 2016
Biochemistry and pharmacology of aminoglycoside-induced hearing loss
1Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109, USA. Schacht@Umich.Edu
Abstract:
Discovered in the 1940s, the aminoglycoside antibiotics were the long-sought remedy for tuberculosis and other serious bacterial infections. They are still one of the most commonly used antibiotics today, thanks to the combination of their high efficacy with low cost. This review begins by addressing some of the history and the acute side effects of aminoglycosides. It then details their chronic toxicity to the inner ear (ototoxicity). The review concludes with recent advances that have demonstrated free-radical reactions as the underlying mechanism and intervention with antioxidant/chelation therapy to prevent aminoglycoside ototoxicity.
Related Concept Videos
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Estimation of k and VD of Aminoglycosides
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Drug Toxicity: Dose-Dependent Reactions
Inhibitors of Bacterial Protein Synthesis
Antifungal Agents

