Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Analgesic principle from Abutilon indicum.

M Ahmed1, S Amin, M Islam

  • 1Department of Pharmacy, University of Dhaka, Bangladesh. deanphrm@du.bangla.net

Die Pharmazie
|May 8, 2000
PubMed
Summary

Eugenol, isolated from Abutilon indicum, demonstrates significant pain relief properties. This natural compound effectively reduced pain responses in mice through two established pain models, highlighting its potential as an analgesic agent.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial Sensitivity Pattern in Neonatal Sepsis in Neonatal Intensive Care Unit of Mymensingh Medical College Hospital.

Mymensingh medical journal : MMJ·2020
Same author

A possible mechanism for Inv22-related F8 large deletions in severe hemophilia A patients with high responding factor VIII inhibitors.

Journal of thrombosis and haemostasis : JTH·2012
Same author

Prevalence and associations of the metabolic syndrome among patients prescribed clozapine.

Irish journal of medical science·2008
Same author

Respiratory muscle weakness in a patient with quiescent Crohn's disease and pneumonia.

QJM : monthly journal of the Association of Physicians·2008
Same author

Seroprevalence of rubella among urban and rural Bangladeshi women emphasises the need for rubella vaccination of pre-pubertal girls.

Indian journal of medical microbiology·2008
Same author

Patients on hemodialysis visiting madina munawarah: communication between nephrologists.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia·2008

Area of Science:

  • Pharmacology
  • Natural Product Chemistry
  • Pain Research

Background:

  • Abutilon indicum is a plant traditionally used for medicinal purposes.
  • Natural products are a rich source of novel therapeutic agents.
  • Understanding the pharmacological properties of plant-derived compounds is crucial for drug discovery.

Purpose of the Study:

  • To isolate and identify bioactive compounds from Abutilon indicum.
  • To evaluate the analgesic activity of the isolated compound, eugenol.
  • To investigate the efficacy of eugenol in established animal models of pain.

Main Methods:

  • Bioactivity-guided fractionation of Abutilon indicum extract.
  • Chemical identification of the active compound as eugenol (4-allyl-2-methoxyphenol).

Related Experiment Videos

  • Assessment of analgesic activity using acetic acid-induced writhing test and radiant heat tail flick test in mice.

    • Main Results:

    • Eugenol significantly inhibited acetic acid-induced writhing in a dose-dependent manner (21.30% at 10 mg/kg, 42.25% at 30 mg/kg, and 92.96% at 50 mg/kg).
    • Eugenol demonstrated a significant increase in tail flicking time (33.40% at 50 mg/kg) in the radiant heat tail flick test.
    • The results indicate potent analgesic effects of eugenol.

    Conclusions:

    • Eugenol, isolated from Abutilon indicum, possesses significant analgesic properties.
    • Eugenol's pain-relieving effects were confirmed in both chemical and thermal pain models.
    • This study supports the traditional use of Abutilon indicum and highlights eugenol as a promising candidate for further development as a natural analgesic.