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Risk adapted management with adjuvant chemotherapy in patients with high risk clinical stage i nonseminomatous germ
U E Studer1, F C Burkhard, R W Sonntag
1Department of Urology, University of Berne, Inselspital-Anna Seiler-Haus, Berne, Switzerland.
Purpose:
We propose that patients with high risk, clinical stage I nonseminomatous germ cell tumors receive 2 cycles of chemotherapy initially, instead of undergoing surgery or observation.
Materials And Methods:
A total of 59 patients with high risk, clinical stage I nonseminomatous germ cell tumor received risk adapted adjuvant chemotherapy. Until June 1987, 20 patients were treated with 2 courses of adjuvant cisplatin, vinblastine and bleomycin at 3-week intervals. After June 1987 another 39 patients were treated with 2 cycles of bleomycin, etoposide and cisplatin.
Results:
Long-term results with this treatment strategy have been excellent with limited morbidity.
Conclusions:
Adjuvant chemotherapy may be of particular value in patients with compromised followup.
